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Enzymes in amniotic fluid.

B F Watkins, E W Bermes

    Annals of Clinical and Laboratory Science
    |May 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Enzyme analysis in amniotic fluid aids in assessing fetal maturity and well-being. Specific enzyme levels can diagnose genetic disorders and complications like rhesus isoimmunization and fetal death.

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    Area of Science:

    • Biochemistry
    • Prenatal Diagnostics
    • Fetal Medicine

    Background:

    • Enzyme levels in amniotic fluid are crucial for monitoring fetal development.
    • Established enzyme markers correlate with gestational age and fetal maturity.
    • Prenatal diagnosis of genetic disorders relies on enzymatic analysis.

    Purpose of the Study:

    • To highlight the utility of amniotic fluid enzyme determination.
    • To establish enzyme activity relationships with fetal maturity and well-being.
    • To demonstrate the application of enzyme analysis in prenatal diagnosis.

    Main Methods:

    • Analysis of enzyme activities in cell-free amniotic fluid.
    • Correlation of enzyme levels with gestational age.
    • Measurement of specific enzyme ratios (e.g., diamine oxidase).

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    Main Results:

    • Enzyme activities (amylase, alpha-galactosidase, etc.) increase with gestational age.
    • Amniotic fluid diamine oxidase/serum diamine oxidase ratio indicates rhesus isoimmunization.
    • Elevated creatine phosphokinase signifies in utero fetal death.

    Conclusions:

    • Amniotic fluid enzyme analysis is a valuable tool for fetal assessment.
    • Enzyme profiling aids in the prenatal diagnosis of various genetic disorders.
    • Specific enzyme markers provide critical information on fetal health and maturity.