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Related Concept Videos

Metal-Ligand Bonds02:51

Metal-Ligand Bonds

The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
Drug-Receptor Bonds01:25

Drug-Receptor Bonds

Drug-receptor bonds are formed through various chemical forces when drugs interact with target cells. Covalent bonds, strong and irreversible, are exemplified by DNA-alkylating anticancer agents that inhibit cell division. However, such irreversible drug binding lacks selectivity and can modify the DNA of the surrounding healthy cells. Covalent binding often contributes to tissue toxicity, as seen with chloroform and paracetamol metabolites binding to the liver, causing hepatotoxicity.
In...
Valence Bond Theory02:42

Valence Bond Theory

Coordination compounds and complexes exhibit different colors, geometries, and magnetic behavior, depending on the metal atom/ion and ligands from which they are composed. In an attempt to explain the bonding and structure of coordination complexes, Linus Pauling proposed the valence bond theory, or VBT, using the concepts of hybridization and the overlapping of the atomic orbitals. According to VBT, the central metal atom or ion (Lewis acid) hybridizes to provide empty orbitals of suitable...
EDTA: Chemistry and Properties01:22

EDTA: Chemistry and Properties

Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...
Complexation Equilibria: Factors Influencing Stability of Complexes01:09

Complexation Equilibria: Factors Influencing Stability of Complexes

In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...

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Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
11:14

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

Unusual DNA binding modes for metal anticancer complexes.

Ana M Pizarro1, Peter J Sadler

  • 1Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK.

Biochimie
|April 7, 2009
PubMed
Summary
This summary is machine-generated.

Metal-based drugs target DNA, with new platinum and ruthenium complexes offering novel therapeutic strategies. These include photoactivated chemotherapy and unique DNA interactions for enhanced cancer treatment.

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Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
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Last Updated: Jun 24, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
11:14

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

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Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
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Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

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Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
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Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Published on: September 7, 2019

Area of Science:

  • Medicinal Chemistry
  • Molecular Biology
  • Biochemistry

Background:

  • DNA is a key target for metal-based therapeutic agents.
  • Platinum-based drugs like cisplatin induce apoptosis via DNA damage.
  • Novel metal complexes are being developed to overcome drug resistance and improve efficacy.

Purpose of the Study:

  • To explore novel metal-based drugs targeting DNA.
  • To investigate new platinum complexes with unique DNA interaction modes.
  • To examine ruthenium and osmium complexes for anticancer potential.

Main Methods:

  • Design and synthesis of novel platinum(IV) pro-drugs for photoactivated chemotherapy.
  • Characterization of trinuclear platinum complex BBR3464's interaction with DNA.
  • Investigation of ruthenium(II) and osmium organometallic complexes' DNA binding and cytotoxicity.

Main Results:

  • Platinum(IV) pro-drugs generate unique DNA lesions upon light activation, evading repair mechanisms.
  • BBR3464 exhibits novel DNA interaction modes.
  • Ruthenium(II) complexes bind DNA via coordination, H-bonding, and hydrophobic interactions.
  • Osmium complexes show cytotoxic potential through different DNA interactions.

Conclusions:

  • Novel metal-based drugs, including platinum and ruthenium complexes, offer promising avenues for cancer therapy.
  • Photoactivated chemotherapy presents a new strategy for targeted cancer treatment.
  • Understanding metal-DNA interactions is crucial for designing next-generation therapeutics.