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Related Experiment Video

Updated: Jun 24, 2026

Large Scale Zebrafish-Based In vivo Small Molecule Screen
07:03

Large Scale Zebrafish-Based In vivo Small Molecule Screen

Published on: December 30, 2010

Large-scale small-molecule screen using zebrafish embryos.

Charles C Hong1

  • 1Division of Cardiovascular Medicine, Department of Pharmacology, Vanderbilt University School of Medicine, 383 Preston Research Building, 2220 Pierce Avenue, Nashville, TN 37232, USA. charles.c.hong@vanderbilt.edu

Methods in Molecular Biology (Clifton, N.J.)
|April 7, 2009
PubMed
Summary
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Zebrafish embryos are valuable for large-scale chemical screens due to their similarities to mammals and susceptibility to small molecules. These screens can uncover new biological insights and potential therapeutic compounds.

Area of Science:

  • Comparative biology
  • Pharmacology
  • Developmental biology

Background:

  • Zebrafish share significant molecular, morphological, and physiological similarities with mammals.
  • Zebrafish are highly responsive to small molecule perturbations, including clinical pharmaceuticals.

Purpose of the Study:

  • To highlight the utility of zebrafish embryos for large-scale phenotype-based screens.
  • To demonstrate the potential of zebrafish chemical screens in discovering novel biological pathway insights and therapeutic leads.

Main Methods:

  • Utilizing zebrafish embryos for their small size and transparency.
  • Employing phenotype-based screening for small-molecule modifiers.
  • Analogy to classical genetic screens for chemical approaches.

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A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos
07:45

A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos

Published on: November 8, 2014

Development of automated imaging and analysis for zebrafish chemical screens.
10:49

Development of automated imaging and analysis for zebrafish chemical screens.

Published on: June 24, 2010

Related Experiment Videos

Last Updated: Jun 24, 2026

Large Scale Zebrafish-Based In vivo Small Molecule Screen
07:03

Large Scale Zebrafish-Based In vivo Small Molecule Screen

Published on: December 30, 2010

A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos
07:45

A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos

Published on: November 8, 2014

Development of automated imaging and analysis for zebrafish chemical screens.
10:49

Development of automated imaging and analysis for zebrafish chemical screens.

Published on: June 24, 2010

Main Results:

  • Zebrafish embryos facilitate large-scale screens for small-molecule modifiers.
  • Chemical screens in zebrafish can reveal novel biological pathway information.
  • Identification of potential lead compounds for novel therapeutics is feasible.

Conclusions:

  • Zebrafish are a versatile model for chemical screens.
  • Zebrafish chemical screens offer a powerful approach for biological discovery and drug development.
  • This model system holds promise for advancing our understanding of complex biological processes.