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Updated: Jun 24, 2026
09:11
Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
Published on: February 13, 2016
A robust, electrochemically driven microwell drug delivery system for controlled vasopressin release
Aram J Chung1, Yun Suk Huh, David Erickson
1Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853, USA.
Biomedical Microdevices
|April 9, 2009
Summary
This study introduces a novel micro-electro-mechanical-system (MEMS) implantable drug delivery device. It utilizes an electrochemical mechanism for precise, rapid drug release, overcoming limitations of current technologies.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Current implantable drug delivery systems face challenges in precise dose control, release timing, and power efficiency.
- Micro-electro-mechanical-systems (MEMS) offer potential for miniaturized, controlled drug delivery solutions.
Purpose of the Study:
- To develop and characterize an implantable micro-reservoir device for controlled drug delivery.
- To demonstrate an electrochemical transport mechanism for active dose rate control.
Main Methods:
- Fabrication of a MEMS-based micro-reservoir device.
- Utilized an electrochemical transport mechanism for drug ejection.
- Characterized device performance including volume transport rate, concentration profiles, power consumption, and ejection efficiency.
- Evaluated in-vitro release of vasopressin.
Main Results:
- Demonstrated successful delivery of up to 15 microliters of therapeutic compound.
- Achieved significant reduction in drug delivery time, independent of physiological conditions.
- Quantified volume transport rate as a function of applied electric field strength.
- Investigated power consumption and ejection efficiency.
Conclusions:
- The developed MEMS device offers a robust, low-power solution for precise, active control of drug delivery.
- Electrochemical transport mechanism enables rapid and controlled release, enhancing therapeutic potential.
- The device shows promise for various medical applications requiring localized and timed drug administration.
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