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Updated: Jun 24, 2026

Ferric Chloride-induced Murine Thrombosis Models
Published on: September 5, 2016
Pomegranate fruit components modulate human thrombin
M Cuccioloni1, M Mozzicafreddo, L Sparapani
1Department of Molecular, Cellular & Animal Biology, University of Camerino, Italy.
Abstract:
Pomegranate (Punica granatum) is an important source of polyphenols with assessed antioxidant properties. The aims of this study were: (i) the characterization of the monomeric phenolic variability on each isolated fruit component (endocarp, mesocarp, aril); (ii) the study on the effect of pomegranate fruit components on human thrombin amidolytic activity. Collectively, our data show that pomegranate components contain bioactive metabolites (mainly ellagic acid) and suggest a potential role for the pomegranate extract in the regulation of a number of physio-pathological processes involving thrombin (or thrombin-like proteinase).
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