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The ups and downs of p53: understanding protein dynamics in single cells
Eric Batchelor1, Alexander Loewer, Galit Lahav
1Harvard Medical School Systems Biology, Boston, MA 02115, USA.
Abstract:
Cells living in a complex environment must constantly detect, process and appropriately respond to changing signals. Therefore, all cellular information processing is dynamic in nature. As a consequence, understanding the process of signal transduction often requires detailed quantitative analysis of dynamic behaviours. Here, we focus on the oscillatory dynamics of the tumour suppressor protein p53 as a model for studying protein dynamics in single cells to better understand its regulation and function.
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