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Mid-dermal elastolysis in a patient undergoing chronic hemodialysis
Philip A Eaton1, Alfred L Knable, Jeffrey P Callen
1Division of Dermatology, Department of Medicine, University of Louisville, Kentucky, USA. philipeaton@hotmail.com
Cutis
|April 15, 2009
Summary
Mid-dermal elastolysis (MDE) is a rare skin disorder. This case highlights an unusual presentation of MDE in a patient undergoing hemodialysis, suggesting a potential link and implicating matrix metalloproteinase dysfunction.
Area of Science:
- Dermatology
- Pathology
Background:
- Mid-dermal elastolysis (MDE) is a rare acquired skin condition of unknown cause.
- It typically manifests as wrinkled patches or perifollicular papules on the trunk and arms.
Observation:
- A patient presented with atypical urticarial papules and plaques.
- These clinical features were histopathologically confirmed as MDE.
Findings:
- This represents the first reported case of MDE presenting with urticarial lesions.
- The patient was undergoing hemodialysis, suggesting a potential novel association.
- Matrix metalloproteinase (MMP) dysfunction is proposed as a key factor in MDE pathogenesis.
Implications:
- This case expands the clinical spectrum of MDE.
- It suggests a possible link between MDE and hemodialysis.
- Further research into MMPs may elucidate MDE's underlying mechanisms.
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