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Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

Ethical Issues

Ethical Issues

Nurses are essential in patient care, upholding the ethical principles of their profession and effectively navigating ethical dilemmas. Neglecting ethical issues can lead to inadequate patient care, compromised therapeutic relationships, and moral distress among healthcare workers.
Ethical Concerns in Healthcare:

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

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Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy

Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy

Published on: January 25, 2019

Ethical issues in stem cell research.

Bernard Lo¹, Lindsay Parham

¹University of California San Francisco Program in Medical Ethics, San Francisco, California 94143, USA. bernard.lo@ucsf.edu

Endocrine Reviews

|April 16, 2009

Summary

This summary is machine-generated.

Human stem cell (hSC) research holds therapeutic promise but faces ethical controversies. This analysis examines policy challenges in hSC research, from derivation to clinical application, ensuring ethical practices.

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Culture and Maintenance of Human Embryonic Stem Cells

Culture and Maintenance of Human Embryonic Stem Cells

Published on: December 22, 2009

Area of Science:

Biomedical Ethics
Developmental Biology
Regenerative Medicine

Background:

Human stem cell (hSC) research offers potential treatments for diseases like diabetes and Parkinson's.
Ethical and political controversies surround hSC research, particularly concerning embryonic stem cells.
Induced pluripotent stem cells (iPSCs) offer an alternative, avoiding some ethical dilemmas.

Purpose of the Study:

To critically analyze the ethical and policy issues in human stem cell research.
To examine how current policies address dilemmas in hSC research.
To ensure ethically appropriate conduct in stem cell research.

Main Methods:

Policy analysis of ethical considerations in hSC research.
Review of ethical disputes regarding stem cell derivation and use.
Examination of consent, clinical trials, and oversight in hSC research.

Main Results:

Ethical controversies exist regarding the derivation of pluripotent stem cells from embryos.
Dilemmas arise in downstream research, material donation consent, early clinical trials, and oversight.
Induced pluripotent stem cells mitigate some, but not all, ethical concerns.

Conclusions:

Ethical and policy issues must be addressed alongside scientific challenges in hSC research.
Current policies require critical analysis to ensure ethical stem cell research practices.
A balanced approach is needed to harness the therapeutic potential of stem cells responsibly.