Related Experiment Video
Updated: Jun 24, 2026

Isolation of Mouse Retinal Capillaries and Subendothelial Matrix for Stiffness Measurement Using Atomic Force Microscopy
Published on: July 12, 2024
Carotid stiffness and microalbuminuria in patients with type 2 diabetes
Wei-Wei Zhan1, Yu-Hong Chen, Yi-Fei Zhang
1Department of Ultrasonography, Ruijin Hospital, Shanghai Jiaotong University Medical School, Shanghai 200025, People's Republic of China.
Abstract:
Microalbuminuria is associated with higher cardiovascular mortality, especially in diabetics. But the direct association between microalbuminuria and vascular wall properties is still not clear. We investigated quantitative carotid stiffness (QCS) index in relation to microalbuminuria in 260 Chinese diabetic patients. In categorical analyses, patients with elevated urinary albumin-to-creatinine ratio (uACR) had higher QCS than those with normal uACR (P < 0.001). The corresponding values for QCS values were 4.4 and 5.9, respectively. In multiple stepwise regression analyses, QCS was significantly associated with age, uACR, plasma glycosylated hemoglobin A(1C) (HbA(1C)), and current smoking (P < 0.05 for all). In conclusion, carotid stiffness as measured by QCS, a local functional measurement of the arterial wall, is increased in type 2 diabetes with microalbuminuria.
Related Concept Videos
Diabetic Nephropathy
Diabetic Retinopathy
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
Chronic Kidney Disease II: Clinical Manifestations
Type II Diabetes II: Pathophysiology
Type I Diabetes II: Pathophysiology
