Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Experimental cochlear damage by neomycin ear drops].

E Yaniv1, R Kol

  • 1ENT Dept., Soroka Medical Center, Beer Sheba.

Harefuah
|May 15, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-estrogen therapy for hereditary hemorrhagic telangiectasia - a long-term clinical trial.

Rhinology·2011
Same author

Sublabial approach for columellar reconstruction in corrective rhinoplasty.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2008
Same author

[(123)I]-FP-CIT SPECT and olfaction test in patients with combined postural and rest tremor.

Journal of neural transmission (Vienna, Austria : 1996)·2008
Same author

The use of doxycycline in periodontology. Histologic in vivo study on mice affected by diabetes mellitus.

Minerva stomatologica·2006
Same author

The interference of medical radionuclides with occupational in vivo gamma spectrometry.

Health physics·2003
Same author

[The endoscopic approach to isolated sphenoid sinus disease].

Harefuah·2002
Same journal

[Tennis Elbow Among Players].

Harefuah·2026
Same journal

[Internal Medicine - My Mission].

Harefuah·2026
Same journal

[Treatment of Morbid Obesity in Israel: GLP-1 Agonists Versus Bariatric Surgery - Clinical and Economic Aspects].

Harefuah·2026
Same journal

[Baby steps: Post-operative Treatment Recommendations for Pediatric Tracheostomy in Israel].

Harefuah·2026
Same journal

[Mastoiditis Caused by Fusobacterium Necrophorum: an Unusual Pathogen in a Well-Known Disease].

Harefuah·2026
Same journal

[Cochlear Implantation in Single-Sided Deafness - Six Years of Follow-Up from Diagnosis and Consistent Use, Through Dedicated and Creative Auditory Learning, to the Development of Bilateral Central Processing Abilities].

Harefuah·2026
See all related articles

Neomycin ear drops can damage the cochlea in guinea pigs, affecting hearing. Even a single exposure damages supporting cells, leading to hearing loss.

Area of Science:

  • Ototoxicity
  • Auditory Neuroscience
  • Pharmacology

Background:

  • Neomycin sulfate is a common antibiotic used in ear drops.
  • Potential ototoxicity of neomycin sulfate necessitates investigation into its effects on the cochlea.

Purpose of the Study:

  • To evaluate the cochlear damage caused by neomycin sulfate solution at concentrations found in ear drops.
  • To determine the effects of varying exposure levels of neomycin sulfate on cochlear structures.

Main Methods:

  • Cochlear damage was assessed in 28 guinea pigs following exposure to neomycin sulfate solutions.
  • Control solutions included neomycin sulfate with dexamethasone sodium and physiologic salt solutions.

Main Results:

  • Neomycin sulfate solutions, but not controls, caused cochlear damage, even after a single exposure.

Related Experiment Videos

  • Initial damage targeted supporting cells, progressing to hair cell damage and hair loss with increased exposure.
  • Neomycin was absorbed from the middle ear to the inner ear, causing cochlear damage.

    • Conclusions:

    • Neomycin sulfate exhibits ototoxic properties, damaging the cochlea through absorption from the middle ear.
    • Damage to supporting cells and/or hair cells by neomycin sulfate leads to hearing loss.
    • Increased exposure duration to neomycin sulfate exacerbates cochlear damage and hearing impairment.