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Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
[Protection against uterine cervical cancer by HPV vaccines]
1Department of Obstetrics and Gynecology, School of Medicine, Kanazawa University. masaki-i@med.kanazawa-u.ac.jp
Abstract:
Research literature has definitively shown HPV to be a necessary cause of cervical cancer. HPV is highly prevalent in sexually active populations and its natural history is now traceable thanks to recent advances in technology. HPV-like particle can now be synthesized and assembled in vitro to constitute the major virion protein L1, and this technology has been exploited to produce HPV-L1-VLP vaccines. Now, HPV-related diseases can thus be prevented by commercially available HPV prophylactic vaccines such as Gardasil (recombinant HPV genotype 6/11/16/18) and Cervarix (recombinant HPV genotype 16/18). These advances have dramatically changed the administration of cervical cancer screening programs.
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