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[Systemic proliferating angioendotheliomatosis].

G Kolde1

  • 1Hautklinik, Universität Münster.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|September 1, 1991
PubMed
Summary

Angioendotheliomatosis proliferans systematisata, a rare condition, is identified as a malignant angiotropic lymphoma. This neurocutaneous manifestation involves atypical B-lymphocytes within skin blood vessels.

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Area of Science:

  • Hematology
  • Dermatology
  • Neurology

Background:

  • Angioendotheliomatosis proliferans systematisata (APS) is a rare clinicopathological entity characterized by endothelial proliferation.
  • The exact nature and origin of the proliferating cells in APS have been a subject of debate.

Observation:

  • A 75-year-old female presented with neurological disturbances and multiple erythematous skin lesions.
  • Histological examination revealed intravascular tumor cells within cutaneous blood vessels, leading to the diagnosis of APS.

Findings:

  • Immunohistochemistry and electron microscopy identified the intravascular tumor cells as atypical B-lymphocytes.
  • The findings support APS as a malignant angiotropic lymphoma.

Implications:

  • This case highlights the neurocutaneous manifestations of malignant angiotropic lymphoma.
  • Further research into the pathogenesis and treatment of APS is warranted.

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