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Published on: May 26, 2023
[Eales' disease--10 years experience with a rare disease]
B M Stoffelns1, C Kramann, K Schoepfer
1Augenklinik der Johannes-Gutenberg-Universität, Mainz. stoffelns@augen.klinik.unimainz.de
Klinische Monatsblatter Fur Augenheilkunde
|April 23, 2009
Summary
Early treatment of Eales' disease with laser, cryocoagulation, and vitrectomy stabilizes the retina and improves vision. This vasoproliferative retinal disease may involve coagulopathy.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Vasoproliferative Disorders
Background:
- Eales' disease is an uncommon vasoproliferative retinal condition.
- It primarily affects young, otherwise healthy males.
- This study reports treatment outcomes in a large patient cohort with long-term follow-up.
Purpose of the Study:
- To analyze treatment results for Eales' disease.
- To evaluate the efficacy of various interventions including laser, cryocoagulation, and vitrectomy.
- To assess long-term outcomes and visual acuity in patients with Eales' disease.
Main Methods:
- Retrospective analysis of 50 eyes from 35 patients treated between May 1995 and August 2005.
- Data collected included patient demographics, systemic associations, medications, laboratory findings, and surgical treatments.
- Mean follow-up duration was 5.8 years.
Main Results:
- Factor V Leiden mutation, vestibuloauditory issues, and migraine were identified in some patients.
- Scatter laser photocoagulation was used for peripheral non-perfusion and mild neovascularization.
- Advanced neovascularization and vitreous hemorrhage cases received cryocoagulation and/or vitrectomy, with 5 eyes requiring silicone oil tamponade.
- All treated eyes achieved stabilization without further bleeding.
- Visual acuity improved in 25 eyes, with the best outcomes observed after vitrectomy.
Conclusions:
- Early intervention with retinal laser, cryocoagulation, and timely vitrectomy can stabilize Eales' disease.
- These treatments can lead to improved visual acuity.
- Coagulopathy may play a role in the pathogenesis of Eales' disease.
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