Related Experiment Video
Updated: Jun 23, 2026

A Bacterial Oral Feeding Assay with Antibiotic-Treated Mosquitoes
Published on: September 12, 2020
[Treatment of community acquired bacterial meningitis, after microbiological identification]
1Service des maladies infectieuses et tropicales, CHU et université Joseph-Fourier, 38043 Grenoble, France. JPStahl@chu-grenoble.fr
Introduction:
Are the 1996 SPILF consensus conference recommendations on bacterial meningitis (BM) still adequate?
Objective:
The literature published after 1996 was analyzed and the reviewers summarized the available data on antibiotic treatment once BM microbiological diagnosis made or strongly suspected.
Method:
A review was made using PubMed, 10,015 references were examined. Only articles published after 1997 were analyzed.
Results:
No study allowed to recommend other regimens than those previously recommended in 1996, in case of meningococcal or pneumococcal infection: 3rd generation cephalosporin or amoxicillin, combined with vancomycin in case of penicillin-intermediate or resistant pneumococcus. In some cases, alternatives are possible, in case of pneumococcal infection: meropenem or antipneumococcal fluoroquinolone were recommended by US guidelines. New antibiotics available on the market were tested using experimental pneumococcal meningitis models: daptomycin and ertapenem seemed to be useful but linezolid was not. Among the antibiotic combinations tested, ceftriaxone+rifampicine demonstrated a better efficacy than ceftriaxone+vancomycin. There was not contributive published data on the length of treatment for bacterial meningitis.
Conclusion:
No assessed arguments could be found to modify previous guidelines. In case of problem with penicillin-resistant pneumococci, penem or a combination using ceftriaxone and rifampicin may be used.
Related Concept Videos
Bacterial Meningitis I: Introduction
Viral Meningitis
Bacterial Meningitis
Bacterial Meningitis II: Pathophysiology
Cryptococcal Meningitis
Acute Pyelonephritis II: Diagnostic Studies and Management