Serum beta2-microglobulin measured by immunonephelometry: expression patterns and reference intervals in healthy...

Area of Science:

• Clinical Chemistry
• Immunology
• Biomarker Research

Background:

• Serum beta2-microglobulin (beta2m) is a key marker for disease activity in various conditions.
• Limited data exists on beta2m expression in healthy individuals.
• Variability in reference limits complicates interpretation.

Purpose of the Study:

• To determine serum beta2m concentrations in healthy adults.
• To investigate the relationship between beta2m levels and age.
• To establish age-specific reference intervals for beta2m.

Main Methods:

• Serum beta2m was measured using immunonephelometry.
• 183 healthy blood donors aged 29-75 years were included.
• Data was analyzed for age and sex differences.

Main Results:

• Median beta2m was 1.67 mg/L, with no significant sex difference.
• A significant positive correlation was found between beta2m and age.
• Age-adjusted reference intervals were established, differing for younger and older adults.

Conclusions:

• Serum beta2m concentrations increase with age in healthy individuals.
• Age-specific reference limits for beta2m can improve clinical study comparisons.
• Standardized reference limits support accurate disease monitoring.