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Updated: Jun 23, 2026
08:40
Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
[Linear IgA disease with ocular involvement associated with ulcerative colitis].
A Klein1, S M Wenzel, E M Messmer
1Klinik und Poliklinik für Dermatologie, Klinikum der Universität Regensburg, Regensburg, Deutschland. annette.klein@klinik.uni-regensburg.de
Summary
Linear IgA disease (LAD) associated with ulcerative colitis and ocular scarring is rare. Dapsone effectively treated a patient
Area of Science:
- Ophthalmology
- Gastroenterology
- Immunodermatology
Background:
- Ulcerative colitis (UC) is a chronic inflammatory bowel disease.
- Linear IgA disease (LAD) is a rare autoimmune blistering disease.
- The co-occurrence of UC, LAD, and ocular involvement presents unique challenges.
Observation:
- A 48-year-old male with a history of UC treated with methylprednisolone developed ocular inflammation, conjunctival scarring, and vesicles.
- Azathioprine was added but did not control the condition.
- Linear IgA disease (LAD) was diagnosed.
Findings:
- Dapsone therapy was initiated after the LAD diagnosis.
- The patient experienced significant reduction in ocular inflammation.
- Methylprednisolone dosage was tapered successfully without disease recurrence.
Implications:
- Dapsone is a potential therapeutic option for managing rare UC-LAD-ocular involvement.
- This case highlights the importance of considering LAD in UC patients with ocular complications.
- Successful management may involve a multi-specialty approach.
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