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Updated: Jun 23, 2026
11:02
Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
Metabolomics: moving to the clinic
Anders Nordström1, Rolf Lewensohn
1Department for Oncology-Pathology, Karolinska Biomics Center, Karolinska Institutet, Z5:02, 17176 Stockholm, Sweden. anders.nordstrom@ki.se
Summary
Metabolomics, a powerful tool for analyzing metabolites, aids in disease diagnosis and treatment. This review highlights recent biomarker discoveries for neurological, cardiovascular, and cancer diseases, plus its role in drug development.
Area of Science:
- Biochemistry
- Systems Biology
- Clinical Diagnostics
Background:
- Metabolomics offers molecular insights close to biological phenotypes.
- Metabolite profiling provides a direct link to gene, mRNA, and protein activity.
- It is increasingly used for biomarker discovery and clinical applications.
Purpose of the Study:
- To review analytical strategies in metabolomics.
- To update on recent biomarker findings for various diseases.
- To examine the clinical implications and drug development impact of metabolomics.
Main Methods:
- Global and non-targeted metabolite profiling.
- Analysis of biomarkers for neurological, cardiovascular, and cancer diseases.
- Review of metabolomics applications in drug discovery and toxicology.
Main Results:
- Metabolomics is crucial for identifying diagnostic and therapeutic biomarkers.
- Significant progress has been made in finding disease-specific metabolite biomarkers.
- The field is rapidly advancing, impacting personalized medicine and drug development.
Conclusions:
- Metabolomics is a powerful tool for clinical diagnostics and personalized pharmacology.
- Continued research will enhance biomarker discovery and therapeutic strategies.
- Its integration into drug discovery accelerates the development of new treatments.
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