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Related Concept Videos

Protein and Protein Structure02:15

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...
Protein Folding01:22

Protein Folding

Overview
Protein Folding01:25

Protein Folding

Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
Protein Folding01:22

Protein Folding

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Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:13

Protein Organization

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Updated: Jun 23, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

The sequence-structure relationship and protein function prediction.

M I Sadowski1, D T Jones

  • 1Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA UK.

Current Opinion in Structural Biology
|May 2, 2009
PubMed
Summary
This summary is machine-generated.

Understanding protein sequence, structure, and function is key for prediction methods. This review explores conservation patterns to improve these predictions.

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Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
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Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

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Last Updated: Jun 23, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
05:08

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

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Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Area of Science:

  • Biochemistry
  • Computational Biology
  • Structural Biology

Background:

  • Protein sequence, structure, and function relationships are complex and not fully understood.
  • This complexity poses significant challenges for computational prediction methods.
  • The interplay of physics and evolution shapes these intricate relationships.

Purpose of the Study:

  • To review recent findings on sequence, structure, and function conservation in proteins.
  • To discuss how conservation patterns can enhance protein prediction methods.
  • To bridge the gap between fundamental understanding and practical application in bioinformatics.

Main Methods:

  • Review of recent experimental and theoretical studies.
  • Analysis of sequence conservation data.
  • Examination of structural and functional conservation patterns.

Main Results:

  • Conservation patterns offer insights into protein sequence-structure-function relationships.
  • Identifying conserved elements is crucial for accurate prediction.
  • Recent findings highlight the utility of evolutionary and physical principles.

Conclusions:

  • Improved understanding of conservation aids in developing better protein prediction tools.
  • Integrating sequence, structure, and function conservation is vital for advancing bioinformatics.
  • Further research into these relationships will drive innovation in protein science.