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Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
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Whole blood platelet aggregometry and platelet function testing.

David L McGlasson1, George A Fritsma

  • 1Wilford Hall Medical Center, United States Air Force Lackland AFB, 2200 Berquist Drive, Lackland AFB, TX 78236-9908, USA. david.mcglasson@lackland.af.mil

Seminars in Thrombosis and Hemostasis
|May 2, 2009
PubMed
Summary

Whole blood lumiaggregometry enhances platelet function testing for diagnosing platelet disorders and monitoring antiplatelet therapy. This sensitive method improves specimen management and detects various platelet defects and drug resistance.

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Area of Science:

  • Hematology
  • Clinical Chemistry
  • Diagnostic Medicine

Background:

  • Platelet aggregometry, established in the 1960s, is the standard for diagnosing and monitoring qualitative platelet disorders.
  • Light transmittance aggregometry has limitations in specimen management and sensitivity to platelet secretion impairments.

Purpose of the Study:

  • To highlight the advantages of whole blood lumiaggregometry over traditional methods.
  • To discuss the application of whole blood lumiaggregometry in diagnosing platelet disorders and monitoring antiplatelet therapy.
  • To explore emerging uses of impedance-based whole blood lumiaggregometry for point-of-care testing.

Main Methods:

  • Comparison of light transmittance aggregometry with lumiaggregometry and impedance-based whole blood lumiaggregometry.
  • Utilizing whole blood lumiaggregometry to identify platelet plasma membrane receptor defects, secretion disorders, and storage pool deficiency.
  • Assessing antiplatelet therapy efficacy and resistance using whole blood lumiaggregometry.

Main Results:

  • Whole blood lumiaggregometry offers improved specimen handling and increased sensitivity to impaired platelet granule secretion.
  • It effectively detects congenital and acquired platelet defects, including receptor issues, secretion problems, and storage pool deficiencies.
  • Whole blood lumiaggregometry is valuable for monitoring antiplatelet medications and identifying resistance to aspirin and thienopyridines.

Conclusions:

  • Whole blood lumiaggregometry represents a significant advancement in platelet function analysis.
  • Its enhanced sensitivity and specimen management make it superior to older methods for diagnosing platelet disorders.
  • There is increasing interest in its application for near-patient testing and antiplatelet therapy monitoring.