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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
Published on: May 9, 2025
[Hypertension, HIV infection, and highly active antiretroviral therapy]
José Ignacio Bernardino de la Serna1, Francisco Xavier Zamora, María Luisa Montes
1Unidad VIH, Servicio de Medicina Interna, Hospital Universitario La Paz, Madrid, España. jibernardino.hulp@salud.madrid.org
Abstract:
The decline in mortality resulting from the use of highly active antiretroviral therapy (HAART) has been accompanied by an increase in metabolic complications that produce accelerated atherosclerosis. Hypertension is one of the most important cardiovascular risk factors. Little is known about the impact of HAART on blood pressure, and it is uncertain whether chronic HIV infection or HAART have a role in the development of hypertension. In this study, the research on the relationships between hypertension and HIV infection published to date is reviewed. Antiretroviral therapy appears to have a modest impact on blood pressure and to be partially mediated by the metabolic changes occurring with this treatment.
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