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Related Concept Videos

DNA Packaging00:58

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Genomics02:02

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
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DNA as a Genetic Template02:05

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Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

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Related Experiment Video

Updated: May 12, 2026

CAPRRESI: Chimera Assembly by Plasmid Recovery and Restriction Enzyme Site Insertion
07:37

CAPRRESI: Chimera Assembly by Plasmid Recovery and Restriction Enzyme Site Insertion

Published on: June 25, 2017

Opening windows to the genome.

Iestyn Whitehouse1, Toshio Tsukiyama

  • 1Sloan-Kettering Institute, New York, NY 12750, USA. whitehoi@mskcc.org

Cell
|May 5, 2009
PubMed
Summary
This summary is machine-generated.

Chromatin regulators can change where nucleosomes are positioned in gene promoters. This study shows how nucleosome positioning impacts gene regulation in yeast.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Epigenetics

Background:

  • Nucleosome positioning is crucial for controlling gene expression.
  • Understanding how chromatin structure influences transcription is an active area of research.

Purpose of the Study:

  • To investigate the role of chromatin regulators in nucleosome positioning.
  • To demonstrate the impact of altered nucleosome positioning on transcriptional regulation in Saccharomyces cerevisiae.

Main Methods:

  • Mapping nucleosome positioning across the genome.
  • Analyzing the effects of a specific chromatin regulator on gene promoters.

Main Results:

  • A chromatin regulator was found to alter nucleosome positioning in the promoters of numerous genes.
  • This alteration in nucleosome positioning has significant implications for gene regulation.

Conclusions:

  • Nucleosome positioning is a key mechanism regulated by chromatin modifiers.
  • This study highlights the power of nucleosome mapping in understanding transcriptional control.