Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electroencephalography Microstate Instability and Clinical Outcomes in Individuals at Clinical High Risk of Psychosis.

JAMA psychiatry·2026
Same author

Biophysical Modeling of Excitation/Inhibition Balance and Conversion to Psychosis in the Clinical High Risk Syndrome.

Biological psychiatry·2026
Same author

Baseline Mismatch Negativity Amplitude Predicts Direction and Magnitude of Ketamine Effect in Healthy Volunteers: A Disordinal Effect.

Biological psychiatry·2026
Same author

Cognition and Electrophysiology Clustering in Clinical High Risk for Psychosis Delineates Distinct Dimensions of Heterogeneity: Implications for Multimodal Clustering.

medRxiv : the preprint server for health sciences·2026
Same author

Visual P300 and Risk for Psychosis Onset in Youth at Clinical High Risk.

Biological psychiatry·2026
Same author

Parsing Reward Processing Substages With Multimodal EEG-fMRI.

Human brain mapping·2026

Related Experiment Video

Updated: Jun 23, 2026

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
12:00

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Published on: November 19, 2014

Error detection failures in schizophrenia: ERPs and FMRI.

Daniel H Mathalon1, Kasper W Jorgensen, Brian J Roach

  • 1Psychiatry Service, San Francisco VA Medical Center, and Department of Psychiatry, University of California-San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA. daniel.mathalon@ucsf.edu

International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology
|May 6, 2009
PubMed
Summary

Patients with schizophrenia show deficient self-monitoring, particularly in error processing. Event-related potentials (ERPs) revealed smaller error-related negativity (ERN) in patients, suggesting ERPs may be superior to fMRI for detecting these abnormalities.

More Related Videos

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
13:08

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

Event Related Potentials (ERPs) and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder (ADHD)
10:02

Event Related Potentials (ERPs) and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder (ADHD)

Published on: March 12, 2020

Related Experiment Videos

Last Updated: Jun 23, 2026

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
12:00

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Published on: November 19, 2014

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
13:08

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

Event Related Potentials (ERPs) and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder (ADHD)
10:02

Event Related Potentials (ERPs) and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder (ADHD)

Published on: March 12, 2020

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Psychiatry

Background:

  • Self-monitoring is crucial for goal-directed behavior and is impaired in schizophrenia.
  • Deficits in error monitoring are a key feature of schizophrenia, potentially linked to broader self-monitoring impairments.
  • Previous research indicates reduced error-related negativity (ERN) and altered anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC) activity in schizophrenia during error processing.

Purpose of the Study:

  • To investigate differences in error processing between patients with schizophrenia and healthy controls using both event-related potentials (ERPs) and functional magnetic resonance imaging (fMRI).
  • To compare the sensitivity of ERPs (specifically ERN) and fMRI (ACC and DLPFC activation) in detecting abnormalities in error monitoring in schizophrenia.

Main Methods:

  • 11 patients with schizophrenia and 10 healthy controls performed a Go-NoGo task.
  • Event-related potentials (ERPs) were recorded to measure the error-related negativity (ERN).
  • Functional magnetic resonance imaging (fMRI) was used to measure activity in the anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC) during false alarm errors.

Main Results:

  • The error-related negativity (ERN) was significantly smaller in patients with schizophrenia compared to healthy controls.
  • Contrary to expectations, anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC) activations to errors were not significantly different between groups.
  • Surprisingly, the dorsolateral prefrontal cortex (DLPFC) showed greater activation to errors in patients with schizophrenia than in controls.

Conclusions:

  • Event-related potentials (ERPs), particularly the ERN, may be more sensitive than fMRI in identifying specific error processing abnormalities in schizophrenia.
  • The temporal precision of ERPs allows for the detection of transient neural activity critical for error detection and behavioral adjustment.
  • Findings suggest that while DLPFC activation patterns differ, ERP measures like ERN might offer a more reliable biomarker for error monitoring deficits in schizophrenia.