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Updated: Jun 23, 2026
06:51
Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
Published on: December 10, 2016
[First Danish case of Clostridium difficile ribotype 027]
Lillian M Søes1, Inger Brock, Mia Torpdahl
1Statens Serum Institut, Afdeling for Bakteriologi, Mykologi og Parasitologi, DK-2300 København S.
Ugeskrift for Laeger
|May 8, 2009
Summary
The first Danish case of severe Clostridium difficile-associated diarrhoea (CDAD) caused by the virulent PCR ribotype 027 (CD027) strain was reported. The patient recovered fully after treatment with metronidazole.
Area of Science:
- Infectious Diseases
- Microbiology
- Gastroenterology
Background:
- Clostridium difficile-associated diarrhoea (CDAD) rates have increased globally since 2003.
- A hypervirulent strain, PCR ribotype 027 (CD027), is linked to severe CDAD cases.
- The emergence of CD027 poses a significant public health challenge.
Observation:
- The first documented case of CDAD caused by CD027 in Denmark is presented.
- An 85-year-old female patient admitted for pneumonia developed severe, bloody diarrhoea.
- Antibiotic treatment with penicillin and moxifloxacin preceded the onset of diarrhoea.
Findings:
- Stool sample analysis confirmed the presence of the CD027 strain.
- The patient received a ten-day course of metronidazole.
- Complete recovery from CDAD symptoms was achieved.
Implications:
- This case highlights the geographical spread of the CD027 strain.
- Early diagnosis and appropriate treatment are crucial for managing severe CDAD.
- Surveillance for CD027 is important for public health in Denmark and beyond.
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