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08:51
A Modular Workflow for Quantitative, Structural and Functional Analysis of Leptospira Biofilms
Published on: December 19, 2025
[Concurrent leptospirosis and salmonella infection]
Frederikke Falkencrone Rönsholt1, Jakob B Seidelin, Steen Villumsen
1Herlev Hospital, Gastroenheden, Medicinsk Sektion. frederikkefr@gmail.com
Ugeskrift for Laeger
|May 8, 2009
Summary
A man with sepsis and organ failure was diagnosed with leptospirosis, a rare bacterial infection. Early diagnosis using polymerase chain reaction (PCR) is crucial for effective treatment of this zoonotic disease.
Area of Science:
- Infectious Diseases
- Microbiology
- Public Health
Background:
- Septicemia of unknown origin can present with severe complications, including liver and kidney failure.
- Occupational exposure, such as working in a henhouse, can be a source of zoonotic infections.
Observation:
- A 56-year-old man presented with sepsis and initial signs of liver and kidney failure.
- Salmonella Typhimurium was identified in stool samples.
- Leptospira spp. DNA was detected in urine and blood via PCR.
Findings:
- The case highlights a co-infection or a misdiagnosed primary infection.
- Polymerase chain reaction (PCR) enabled early detection of Leptospira DNA.
- Leptospirosis, though rare, should be considered in patients with relevant animal exposure and unexplained sepsis.
Implications:
- Early diagnosis of leptospirosis via PCR can lead to timely and appropriate treatment.
- This case underscores the importance of considering zoonotic diseases in differential diagnoses for sepsis.
- Public health awareness regarding potential risks associated with animal husbandry is essential.
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