Related Experiment Video

Updated: Jun 23, 2026

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
10:03

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

[Predisposing factors of community acquired bacterial meningitis (excluding neonates)]

M Revest1, C Michelet

  • 1Maladies infectieuses et réanimation médicale, hôpital Pontchaillou, CHU de Rennes, 35033 Rennes cedex, France.

Medecine Et Maladies Infectieuses
|May 8, 2009
PubMed

Insights

Community acquired bacterial meningitis (CABM) risk factors include meningeal defects, ENT infections, and specific patient conditions like age, diabetes, and immune deficiencies. Certain genetic factors also predispose individuals to CABM.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Genetics

Context:

  • Meningeal defects and ENT infections are established risk factors for pneumococcal meningitis.
  • Community-acquired bacterial meningitis (CABM) is influenced by various factors affecting its incidence, bacterial type, prognosis, and recurrence.
  • Specific conditions like cochlear implants, congenital anomalies, and splenectomy increase susceptibility to certain types of meningitis.

Purpose:

  • To identify and elucidate the diverse risk factors contributing to community-acquired bacterial meningitis (CABM).
  • To highlight the interplay between patient-specific conditions, anatomical abnormalities, and genetic predispositions in the development of meningitis.
  • To inform clinical practice regarding diagnosis, prevention, and management strategies for CABM.

Summary:

  • Meningeal defects, ENT infections, and cochlear implants are linked to pneumococcal meningitis.
  • Congenital anomalies in children may present as aseptic meningitis or meningitis caused by Staphylococcus aureus or Enterobacteriaceae, necessitating prompt MRI.
  • Risk factors for CABM in adults over 60 include diabetes, alcoholism, and immune deficiency, with Streptococcus pneumoniae, Listeria monocytogenes, and Enterobacteriaceae being common pathogens.
  • Genetic polymorphisms in complement, properdin, mannose-binding lectin, Fcgamma receptors, and interleukin-1 pathways are associated with increased CABM risk, particularly meningococcal meningitis.

Impact:

  • Understanding these risk factors aids in targeted prevention strategies, especially for high-risk populations.
  • Early identification of congenital anomalies through clinical presentation and imaging can improve patient outcomes.
  • Genetic screening may be considered for individuals with recurrent meningitis, guiding personalized medical management.
  • This comprehensive overview supports improved diagnostic approaches and therapeutic interventions for bacterial meningitis.

More Related Videos

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria11:32

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Published on: February 23, 2014

Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat08:27

Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat

Published on: October 29, 2014

Related Concept Videos

Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...