Wild-derived mouse stocks: an underappreciated tool for aging research

Area of Science:

• Biogerontology
• Animal Models in Aging Research

Background:

• Biomedical research predominantly uses inbred, isogenic laboratory mouse stocks.
• Laboratory mouse models present significant disadvantages for studying complex processes like aging.
• Wild-derived mouse stocks, including wild-caught individuals and their recent progeny, offer potential benefits for aging research.

Purpose of the Study:

• To review the advantages and disadvantages of using standard inbred laboratory mice in aging research.
• To reintroduce the concept of utilizing wild-derived mouse stocks for biogerontology research.
• To provide an overview of recent biogerontological advancements employing wild-derived mouse models.

Main Methods:

• Literature review of established laboratory mouse models in aging research.
• Review of research advocating for the use of wild-derived mouse stocks in biogerontology.
• Synthesis of recent findings from studies utilizing wild-derived mouse stocks for aging research.

Main Results:

• Inbred laboratory mice have inherent limitations that are amplified when studying aging.
• Wild-derived mouse stocks offer unique genetic diversity and potentially more relevant phenotypes for aging studies.
• Recent research highlights the utility of wild-derived stocks in advancing biogerontology.

Conclusions:

• Wild-derived mouse stocks represent a promising avenue for future aging research.
• The use of wild-derived mice can overcome limitations associated with traditional laboratory models.
• Further exploration of wild-derived stocks is crucial for a comprehensive understanding of aging.