Related Experiment Video
Updated: Jun 23, 2026
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
[Expression of IMP3 in osteosarcoma and its clinical significance]
Kang-hua Li1, Yue-ping Huang, Jun Zhang
1Department of Orthopaedics of Xiangya Hospital, Central South University, Changsha, China.
Aim:
To analyze the expressional variability of IMP3 between osteosarcoma and osteochondroma and explore its clinical significance.
Methods:
Paraffin sections from 68 patients with osteosarcoma and 20 patients with osteochondroma were examined for the expression of IMP3 by SP immunohistochemistry.
Results:
The negative, weak positive, moderate positive and strong positive expression rates of IMP3 in 68 patients with osteosarcoma were 4.41% (3/68), 22.06% (15/68), 22.74% (19/68), 45.59% (31/68), respectively, which were significantly higher than those in 20 cases of osteochondroma tissues (P<0.01). The positive expression of IMP3 in osteosarcoma was negative correlation with the 3-year survival rate of osteosarcoma patients after the operation (P<0.01).
Conclusion:
The results suggest that IMP3 plays important roles in the tumorigenesis, progress and prognosis of osteosarcoma, and the expression of IMP3 may be an important feature of osteosarcoma.
