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Published on: February 5, 2015
Chemical constituents of Isodon nervosus and their cytotoxicity
Fu-Lin Yan1, Lan-Qing Guo, Chun-Ming Wang
1Pharmacy College, Xinxiang Medical University, Xinxiang, China. yanfulin03@xxmu.edu.cn
Abstract:
Two new ent-kaurane diterpenoids, 6,20,15alpha-trihydroxy-6,7-seco-1alpha,7-olide-ent-kaur-16-ene (1) and 7beta,12alpha-dihydroxy-6beta,15beta-diacetoxy-7alpha,20-epoxy-ent-kaur-2,16-dien-1-one (2), together with the six known compounds, were isolated from the aerial part of Isodon nervosus. The structures of the new compounds were determined by spectral methods (1D, 2D NMR, and MS). Six compounds were assayed for their cytotoxicity against HL60, SMMC-7721, and HeLa human cell lines. Compounds 5, 7, and 8 showed significant cytotoxicity.
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