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Related Concept Videos

Induced Electric Fields: Applications01:27

Induced Electric Fields: Applications

An important distinction exists between the electric field induced by a changing magnetic field and the electrostatic field produced by a fixed charge distribution. Specifically, the induced electric field is nonconservative because it does not work in moving a charge over a closed path. In contrast, the electrostatic field is conservative and does no net work over a closed path. Hence, electric potential can be associated with the electrostatic field but not the induced field. The following...
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Resting Membrane Potential01:24

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The relative difference in electrical charge, or voltage, between the inside and the outside of a cell membrane, is called the membrane potential. It is generated by differences in permeability of the membrane to various ions and the concentrations of these ions across the membrane.
The Inside of a Neuron is More Negative
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Measuring the Induced Membrane Voltage with Di-8-ANEPPS
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Cellular membrane potentials induced by alternating fields.

C Grosse1, H P Schwan

  • 1Instituto de Física, Universidad Nacional de Tucumán, 4000 San Miguel de Tucumán, Argentina.

Biophysical Journal
|May 12, 2009
PubMed
Summary
This summary is machine-generated.

External electric fields applied to cells are often reduced by membrane conductance and surface effects, especially in low-conductivity media. This finding impacts theories on cell manipulation techniques like pore formation and dielectrophoresis.

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Area of Science:

  • Biophysics
  • Cellular Electrophysiology

Background:

  • Traditional models assume insulating cell membranes and ignore surface conductance.
  • Laplace's equation is typically used to derive membrane potentials from external fields.

Purpose of the Study:

  • To reexamine traditional models of membrane potentials induced by alternating fields.
  • To incorporate membrane conductance, surface admittance, and space charge effects.

Main Methods:

  • Revisiting the theoretical framework for calculating membrane potentials.
  • Analyzing the influence of medium conductivity on field effects.

Main Results:

  • The traditional approach requires significant corrections when the external medium conductivity is low.
  • The electric field effectively applied to the cell membrane is substantially reduced, potentially nullified.
  • This reduction is observed in various cell manipulation techniques.

Conclusions:

  • Current theories of pore formation and weak electric field effects on membranes may need revision.
  • Accounting for membrane and surface properties is crucial for accurate electrokinetic modeling.