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Published on: July 8, 2016
Nanostructured multilayer coatings combining chitosan with bioactive glass nanoparticles
Daniela S Couto1, Natália M Alves, João F Mano
13B's Research Group - Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.
Journal of Nanoscience and Nanotechnology
|May 14, 2009
Summary
Biodegradable multilayer coatings made of chitosan and bioactive glass nanoparticles mimic nacre's structure. These robust, tunable coatings promote apatite formation, enhancing orthopedic implant osteoconductivity.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Growing demand for biomimetic coatings in biomedical applications.
- Need for advanced materials in bone tissue engineering and orthopedic implants.
- Inspiration from nacre's natural 'brick-and-mortar' structure for material design.
Purpose of the Study:
- To develop biodegradable multilayer coatings using chitosan and bioactive glass nanoparticles.
- To investigate the structural and mechanical properties of these coatings.
- To assess the potential of these coatings to induce apatite formation and improve osteoconductivity.
Main Methods:
- Sequential layer-by-layer deposition of polycation (chitosan) and anionic (bioactive glass nanoparticles) components.
- Quartz crystal microbalance (QCM) for monitoring nanostructure formation and viscoelastic properties.
- Immersion in simulated body fluid (SBF) to evaluate apatite induction.
Main Results:
- Tunable and viscoelastic nanostructured multilayers were successfully fabricated.
- Increasing layer-by-layer cycles resulted in controllable nanostructure properties.
- Coatings demonstrated the ability to induce apatite formation in SBF, similar to natural bone mineral.
- The 'brick-and-mortar' inspired structure was confirmed.
Conclusions:
- Biodegradable multilayer coatings combining chitosan and bioactive glass nanoparticles offer a promising biomimetic approach.
- The developed methodology allows for tunable nanostructure fabrication suitable for biomedical applications.
- These coatings show potential for enhancing the osteoconductivity of orthopedic implants and bone scaffolds.
