[Adenylate system of rat liver tissue during chemical carcinogenesis]

The ratio of adenylic nucleotides, activity of adenylatekinase and ATPase were studied in the liver subcellular fractions and in tumours of rats with cancerogenesis induced by diethylnitrozamine and p-dimethylaminoazobenzene. The adenylatekinase activity increases in the liver hyaloplasm of rats with tumours and in the tissue of the tumours themselves, the activity of ATPase is unchanged. An increase in the adenylatekinase activity in hyaloplasm is accompanied by a decrease in the level of ATP with the absence of changes in ADP and AMP, that results in a drop "of the adenylate energy charge" value (Atkinson reflecting the balance of adenyl nucleotides in a cell.