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Updated: Jun 23, 2026
12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
[Disseminated cutaneous granulomatosis].
Anne-Karine Lapointe1, Emmanuel Laffitte
1Service de dermatologie, et vénéréologie, CHUV, 1010 Lausanne.
Revue Medicale Suisse
|May 15, 2009
Summary
Disseminated cutaneous granulomatosis (DCG) are skin diseases with granulomatous inflammation. This review outlines a diagnostic strategy and treatment recommendations for DCG, aiming to identify underlying causes beyond common conditions like sarcoidosis.
Area of Science:
- Dermatology
- Pathology
Context:
- Disseminated cutaneous granulomatosis (DCG) represent a diverse group of skin conditions.
- Histologically, DCG are defined by a granulomatous infiltrate in the skin.
- While sarcoidosis is the most common cause, DCG can arise from various stimuli including infections, inflammation, neoplasms, metabolic, or chemical factors.
Purpose:
- To propose a systematic strategy for the etiological diagnosis of DCG.
- To provide evidence-based therapeutic recommendations for managing DCG.
- To differentiate DCG from other granulomatous skin conditions.
Summary:
- DCG are characterized by granulomatous inflammation in the skin, with sarcoidosis being the most frequent cause.
- Histopathological examination aids in DCG diagnosis but often does not reveal the specific etiological cause.
- This article presents a diagnostic approach and treatment guidelines for DCG based on current literature.
Impact:
- Facilitates accurate etiological diagnosis of complex skin granulomas.
- Improves patient management through targeted therapeutic recommendations.
- Contributes to a better understanding of the diverse causes of granulomatous skin reactions.
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