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Lichen planus and dyslipidaemia: a case-control study.
J Dreiher1, J Shapiro, A D Cohen
1Hospitals Division, Clalit Health Services, Tel Aviv, Israel. jacod@bgu.ac.il
The British Journal of Dermatology
|May 15, 2009
Summary
Lichen planus (LP) is linked to higher rates of dyslipidaemia, a condition affecting blood lipid levels. This study confirms the association in Israel, highlighting a potential health concern for LP patients.
Area of Science:
- Dermatology
- Cardiovascular Health
- Epidemiology
Background:
- Psoriasis, a chronic inflammatory skin condition, has been previously linked to dyslipidaemia.
- Lichen planus (LP) is another chronic inflammatory disorder with potential systemic implications.
Purpose of the Study:
- To investigate the association between lichen planus (LP) and dyslipidaemia in the Israeli population.
- To determine if LP is an independent risk factor for dyslipidaemia.
Main Methods:
- A case-control study was conducted using data from Clalit Health Services in Israel.
- 1477 patients diagnosed with LP were compared to 2856 controls without LP.
- Data on lifestyle factors and comorbidities were collected and analyzed.
Main Results:
- The prevalence of dyslipidaemia was significantly higher in patients with LP (42.5%) compared to controls (37.8%).
- LP remained significantly associated with dyslipidaemia after adjusting for confounders (multivariate OR 1.34).
- The association was statistically significant (P < 0.001).
Conclusions:
- Lichen planus (LP) is significantly associated with dyslipidaemia.
- This finding suggests a potential link between chronic inflammatory skin conditions and lipid metabolism disorders.
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