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Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
Published on: October 20, 2021
Hepatitis vaccination and prophylaxis
Carolyn T Nguyen1, Tram T Tran
1Division of Gastroenterology, Department of Medicine, Cedars-Sinai Medical Center, 8635 W. 3rd Street, Suite 1060W, Los Angeles, CA 90048, USA.
Insights
Prevent viral hepatitis infections like hepatitis A (HAV), hepatitis B (HBV), and hepatitis C (HCV) with current vaccination and prophylaxis strategies. These measures aim to minimize the widespread clinical effects of these common viruses.
Area of Science:
- Hepatology
- Infectious Diseases
- Public Health
Background:
- Hepatitis A virus (HAV), hepatitis B virus (HBV), and hepatitis C virus (HCV) are leading causes of viral hepatitis globally.
- These infections affect hundreds of millions worldwide, leading to significant morbidity.
Purpose of the Study:
- To review and present current recommendations for preventing viral hepatitis.
- To discuss vaccination and prophylaxis strategies for HAV, HBV, and HCV.
Main Methods:
- Review of current clinical guidelines and public health recommendations.
- Synthesis of information on vaccination schedules and post-exposure prophylaxis.
Main Results:
- Vaccination is a primary prevention strategy for HAV and HBV.
- Prophylaxis options exist for HAV and HBV, particularly post-exposure.
- HCV prevention strategies focus on risk reduction and screening.
Conclusions:
- Vaccination and prophylaxis are crucial for controlling HAV and HBV.
- Minimizing the clinical impact of viral hepatitis requires a multi-faceted approach including vaccination and risk mitigation for HCV.
Abstract:
The three most commonly identified causes of viral hepatitis in the United States are hepatitis A virus (HAV), hepatitis B virus (HBV), and hepatitis C virus (HCV). Hundreds of millions of people worldwide are infected by these viruses; many experience illness as a result. This article discusses current recommendations for vaccination and other forms of prophylaxis aimed at minimizing the clinical effects of these viruses.
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