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Related Experiment Video

Updated: Jun 23, 2026

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Published on: October 12, 2018

HIV infection.

Martin Talbot¹

¹Royal Hallamshire Hospital, Sheffield Teaching Hospitals, Sheffield, UK.

BMJ Clinical Evidence

|May 19, 2009

Summary

This summary is machine-generated.

This systematic review evaluates human immunodeficiency virus (HIV) treatments. It found that various antiretroviral regimens and interventions improve outcomes for people with HIV.

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Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

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Published on: December 3, 2019

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Last Updated: Jun 23, 2026

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Published on: October 12, 2018

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

Area of Science:

Infectious Diseases
Immunology
Pharmacology

Background:

Human immunodeficiency virus (HIV) infection typically has an 8-10 year asymptomatic period before progression to Acquired Immunodeficiency Syndrome (AIDS).
Without treatment, approximately 50% of individuals with HIV will develop AIDS and die within 10 years.
Prognosis for treated HIV infection is influenced by patient age, CD4 cell count, and initial viral load.

Purpose of the Study:

To systematically review the effects of preventive interventions for HIV infection.
To evaluate the effectiveness of different antiretroviral drug treatment regimens in managing HIV infection.

Main Methods:

Conducted a systematic literature review searching Medline, Embase, and The Cochrane Library up to June 2007.
Included data from 17 systematic reviews, randomized controlled trials (RCTs), and observational studies.
Incorporated harms alerts from regulatory agencies like the US FDA and UK MHRA.

Main Results:

A GRADE evaluation was performed to assess the quality of evidence for various interventions.
Seventeen studies met the inclusion criteria, providing data on intervention effectiveness and safety.

Conclusions:

The review presents evidence on combination treatments including CCR5 or fusion inhibitors.
Effectiveness of early diagnosis and treatment of sexually transmitted diseases (STDs) was assessed.
Information on early vs. delayed antiretroviral treatment, various triple-drug regimens (NNRTI, NRTI, protease inhibitor-based), post-exposure prophylaxis, and mass STD treatment is provided.