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Depression in children and adolescents
1Concord Clinical School, University of Sydney, Sydney, Australia.
BMJ Clinical Evidence
|May 19, 2009
Summary
This review examines treatments for child and adolescent depression, including medications like fluoxetine and therapies such as cognitive behavioral therapy (CBT), to assess effectiveness and safety.
Area of Science:
- Pediatric Psychiatry
- Clinical Psychology
- Evidence-Based Medicine
Background:
- Child and adolescent depression affects 2-8% of youth, peaking around puberty.
- Recurrence affects 40%, with a third attempting suicide.
- Suicide accounts for 3-4% of deaths in affected children.
Purpose of the Study:
- To systematically review pharmacological, psychological, combination, and complementary treatments for depression in children and adolescents.
- To evaluate treatments for refractory depression in this population.
- To assess the effectiveness and safety of various interventions.
Main Methods:
- Systematic review of literature up to April 2008.
- Searched Medline, Embase, The Cochrane Library, and other databases.
- Included harms alerts from FDA and MHRA.
Main Results:
- 18 systematic reviews, RCTs, or observational studies were included.
- GRADE evaluation was performed to assess evidence quality.
- Effectiveness and safety data were compiled for numerous interventions.
Conclusions:
- The review presents information on the effectiveness and safety of interventions including citalopram, cognitive behavioral therapy (CBT), fluoxetine, and others.
- A wide range of treatments were evaluated, from pharmacotherapy to psychotherapy and complementary therapies.
- This systematic review provides a comprehensive overview of treatment options for pediatric depression.
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