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Updated: Jun 23, 2026
12:55
P50 Sensory Gating in Infants
Published on: December 26, 2013
GORD in children
Yadlapalli Kumar1, Rajini Sarvananthan
1Consultant Paediatrician, Royal Cornwall Hospital, Treliske, Truro, Cornwall, UK.
BMJ Clinical Evidence
|May 19, 2009
Summary
Gastro-oesophageal reflux in infants is common, affecting over half of those aged 0-3 months. This review evaluates treatments like domperidone and proton pump inhibitors for symptomatic infant reflux.
Area of Science:
- Pediatrics
- Gastroenterology
- Evidence-Based Medicine
Background:
- Gastro-oesophageal regurgitation is common in infants, with 51% of 0-3 month olds experiencing daily episodes.
- Symptomatic reflux is defined by frequent regurgitation, crying, discomfort, and back arching.
Purpose of the Study:
- To systematically review the effectiveness and safety of various treatments for symptomatic gastro-oesophageal reflux in infants.
Main Methods:
- Systematic review of 27 studies including systematic reviews, RCTs, and observational studies.
- Searched major databases (Medline, Embase, Cochrane Library) up to August 2007.
- Included harms alerts from FDA and MHRA.
Main Results:
- Evaluated evidence for interventions including domperidone, feed thickeners, H2 antagonists, sleep positioning, metoclopramide, PPIs, sodium alginate, surgery, soy formula, and weight loss.
- Utilized GRADE evaluation for evidence quality.
Conclusions:
- Presents information on the effectiveness and safety of multiple interventions for infant gastro-oesophageal reflux.
- Provides a comprehensive overview to guide clinical decisions.
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