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12:55

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GORD in children

Yadlapalli Kumar1, Rajini Sarvananthan

  • 1Consultant Paediatrician, Royal Cornwall Hospital, Treliske, Truro, Cornwall, UK.

BMJ Clinical Evidence
|May 19, 2009
PubMed

Insights

Gastro-oesophageal reflux in infants is common, affecting over half of those aged 0-3 months. This review evaluates treatments like domperidone and proton pump inhibitors for symptomatic infant reflux.

Area of Science:

  • Pediatrics
  • Gastroenterology
  • Evidence-Based Medicine

Background:

  • Gastro-oesophageal regurgitation is common in infants, with 51% of 0-3 month olds experiencing daily episodes.
  • Symptomatic reflux is defined by frequent regurgitation, crying, discomfort, and back arching.

Purpose of the Study:

  • To systematically review the effectiveness and safety of various treatments for symptomatic gastro-oesophageal reflux in infants.

Main Methods:

  • Systematic review of 27 studies including systematic reviews, RCTs, and observational studies.
  • Searched major databases (Medline, Embase, Cochrane Library) up to August 2007.
  • Included harms alerts from FDA and MHRA.

Main Results:

  • Evaluated evidence for interventions including domperidone, feed thickeners, H2 antagonists, sleep positioning, metoclopramide, PPIs, sodium alginate, surgery, soy formula, and weight loss.
  • Utilized GRADE evaluation for evidence quality.

Conclusions:

  • Presents information on the effectiveness and safety of multiple interventions for infant gastro-oesophageal reflux.
  • Provides a comprehensive overview to guide clinical decisions.
Abstract

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