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Related Concept Videos

What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Gross Anatomy of the Stomach01:16

Gross Anatomy of the Stomach

The human stomach is a vital part of the digestive system, performing multiple functions. It is located within the peritoneum, a serous membrane that lines the abdominal cavity. The stomach plays a central role in processing food substances and interacts with other digestive organs through coordinated digestive processes. The stomach has a characteristic J-shape and is divided into four main regions. The cardia is the first section where the esophagus connects to the stomach and is the entry...
Pyloric Obstruction01:11

Pyloric Obstruction

Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Stomach pH Regulation01:21

Stomach pH Regulation

The human body carefully regulates the internal pH of different organs to maintain homeostasis. For example, while the blood plasma maintains a neutral pH of 7, the stomach lumen has an acidic pH of 1.5 - 3.5. The low pH of stomach lumen helps kill pathogens in the food and break down complex food molecules.
The acid-secreting gastric mucosal epithelial cells (parietal cells) lining the stomach lumen maintain the low pH in the lumen. Numerous ion transporters and channels on these parietal...

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Related Experiment Video

Updated: Jun 23, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
06:21

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform

Published on: May 10, 2024

Stomach cancer.

Charles Bailey1

  • 1John Radcliffe Hospital, Oxford, UK.

BMJ Clinical Evidence
|May 19, 2009
PubMed
Summary
This summary is machine-generated.

This systematic review examines stomach cancer treatments, comparing radical versus conservative surgery and adjuvant chemotherapy. Evidence on effectiveness and safety of various interventions is presented for resectable distal tumors.

Related Experiment Videos

Last Updated: Jun 23, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
06:21

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform

Published on: May 10, 2024

Area of Science:

  • Gastroenterology
  • Surgical Oncology
  • Evidence-Based Medicine

Background:

  • Stomach cancer, primarily adenocarcinoma, includes gastro-oesophageal junction tumors.
  • Incidence varies globally, with higher rates in Japan compared to the UK.
  • Significant sex-based differences in stomach cancer incidence exist.

Purpose of the Study:

  • To systematically review the effects of radical versus conservative surgical resection for stomach cancer.
  • To evaluate the impact of adjuvant chemotherapy in stomach cancer treatment.
  • To assess the effectiveness and safety of various interventions for resectable distal tumors.

Main Methods:

  • Systematic review of 18 studies including systematic reviews, RCTs, and observational studies.
  • Searched major databases (Medline, Embase, Cochrane Library) up to August 2007.
  • Included harms alerts from regulatory agencies (FDA, MHRA).

Main Results:

  • Identified 18 studies meeting inclusion criteria.
  • Performed GRADE evaluation to assess the quality of evidence for interventions.
  • Compiled data on effectiveness and safety of surgical and chemotherapeutic interventions.

Conclusions:

  • Presents information on adjuvant chemoradiotherapy and chemotherapy effectiveness.
  • Summarizes findings on lymphadenectomy (radical vs. conservative) and adjacent organ removal.
  • Provides evidence on subtotal gastrectomy for resectable distal stomach tumors.