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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Related Experiment Video

Updated: Jun 23, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Malignant melanoma (metastatic).

James Larkin1, Martin Gore

  • 1Melanoma Unit, Department of Medicine, Royal Marsden Hospital, London, UK.

BMJ Clinical Evidence
|May 19, 2009
PubMed
Summary
This summary is machine-generated.

This review examines chemotherapy and immunotherapy for metastatic melanoma, a serious cancer. Evidence on effectiveness and safety for treatments like dacarbazine and temozolomide is presented.

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Last Updated: Jun 23, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
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A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs
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Published on: May 24, 2016

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Area of Science:

  • Oncology
  • Clinical Evidence

Background:

  • Malignant melanoma is a significant cause of cancer deaths in the UK, with metastatic disease having a poor prognosis.
  • Current treatments for metastatic melanoma, including chemotherapy, are primarily palliative.

Purpose of the Study:

  • To systematically review the effects of chemotherapy and immunotherapy for metastatic melanoma.
  • To evaluate the effectiveness and safety of various treatment interventions.

Main Methods:

  • A systematic review of literature up to September 2007 was conducted.
  • Searches included Medline, Embase, and The Cochrane Library.
  • Harms alerts from regulatory agencies were also incorporated.

Main Results:

  • Twenty-three systematic reviews, RCTs, and observational studies were included.
  • A GRADE evaluation assessed the quality of evidence for interventions.
  • Information on specific interventions like dacarbazine and temozolomide was compiled.

Conclusions:

  • The review presents data on the effectiveness and safety of multiple interventions for metastatic melanoma.
  • Interventions discussed include interferon alfa, dacarbazine, various chemotherapies, and temozolomide.