Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Traumatic Brain Injury l: Introduction01:28

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MRI Enhancement Associated with TFCC and Scapholunate Interosseous Ligament Tears.

Journal of wrist surgery·2026
Same author

Pyrocarbon shoulder hemiarthroplasty: A surgical technique.

Shoulder & elbow·2026
Same author

PyroTITAN Pyrocarbon Shoulder Hemiarthroplasty: Clinical and Radiographic Outcomes with Medium-Term Follow-up.

The Journal of bone and joint surgery. American volume·2026
Same author

Variation in management of febrile infants younger than 90 days across London: a retrospective cohort study.

European journal of pediatrics·2026
Same author

Reliability of Different Dynamometers Used to Measure Isometric Shoulder Strength: A Comparative Study of Two Dynamometers in 526 Adults.

Cureus·2025
Same author

Midterm Clinical Outcomes of a Resurfacing Capitate Pyrocarbon Implant: A Case Series.

Journal of wrist surgery·2025
Same journal

Rheumatoid arthritis: previously untreated early disease.

BMJ clinical evidence·2016
Same journal

Diabetic retinopathy: intravitreal vascular endothelial growth factor inhibitors for diabetic macular oedema.

BMJ clinical evidence·2016
Same journal

Subarachnoid haemorrhage (spontaneous aneurysmal).

BMJ clinical evidence·2016
Same journal

Malaria: fluid therapy in severe disease.

BMJ clinical evidence·2016
Same journal

Age-related macular degeneration: anti-vascular endothelial growth factor treatment.

BMJ clinical evidence·2016
Same journal

MRSA: treating people with infection.

BMJ clinical evidence·2016
See all related articles

Related Experiment Video

Updated: Jun 23, 2026

Controlled Cortical Impact Model for Traumatic Brain Injury
05:30

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

Head injury (moderate to severe).

Ian Maconochie1, Mark Ross

  • 1Department of Paediatric Accident and Emergency, St Mary's Hospital, London, UK.

BMJ Clinical Evidence
|May 20, 2009
PubMed
Summary
This summary is machine-generated.

This systematic review examines interventions for moderate to severe head injury, assessing treatments like antibiotics and hypothermia to reduce complications and improve outcomes for traumatic brain injury patients.

More Related Videos

Modified Mouse Model of Repetitive Mild Traumatic Brain Injury Incorporating Thinned-Skull Window and Fluid Percussion
04:54

Modified Mouse Model of Repetitive Mild Traumatic Brain Injury Incorporating Thinned-Skull Window and Fluid Percussion

Published on: April 19, 2024

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
09:49

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

Related Experiment Videos

Last Updated: Jun 23, 2026

Controlled Cortical Impact Model for Traumatic Brain Injury
05:30

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

Modified Mouse Model of Repetitive Mild Traumatic Brain Injury Incorporating Thinned-Skull Window and Fluid Percussion
04:54

Modified Mouse Model of Repetitive Mild Traumatic Brain Injury Incorporating Thinned-Skull Window and Fluid Percussion

Published on: April 19, 2024

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
09:49

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

Area of Science:

  • Neuroscience
  • Trauma Care
  • Clinical Evidence

Background:

  • Head injuries are common in young adults (accidents, violence, sports) and older adults (falls).
  • Severe head injury can cause secondary brain damage via ischemia, hypotension, hypercapnia, and increased intracranial pressure.
  • Glasgow Coma Scale (GCS) assesses injury severity; severe injury (GCS < 8) has varied outcomes: 25% good recovery, 33% mortality, 20% severe disability/vegetative state.

Purpose of the Study:

  • To systematically review interventions aimed at reducing complications in moderate to severe head injuries.
  • To evaluate the effectiveness and safety of various treatments for traumatic brain injury.

Main Methods:

  • Systematic review of 17 studies (reviews, RCTs, observational studies) up to April 2007.
  • Searched major databases (Medline, Embase, Cochrane Library).
  • Included safety alerts from regulatory agencies (FDA, MHRA).

Main Results:

  • The review identified 17 studies meeting inclusion criteria.
  • Information was gathered on the effectiveness and safety of specific interventions.

Conclusions:

  • The review provides data on interventions including antibiotics, anticonvulsants, corticosteroids, hyperventilation, hypothermia, and mannitol.
  • This information aids in managing moderate to severe head injuries and their complications.