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05:28
Standard Membrane Feeding Assay for the Detection of Plasmodium falciparum Infection in Anopheles Mosquito Vectors
Published on: May 12, 2022
Malaria: uncomplicated, caused by Plasmodium falciparum
David Taylor-Robinson1, Katharine Jones, Paul Garner
1Liverpool School of Tropical Medicine, Liverpool, UK.
BMJ Clinical Evidence
|May 20, 2009
Summary
Artemisinin combination treatments are effective for malaria in endemic areas. This systematic review compares various artemisinin combination therapies to guide treatment decisions for uncomplicated malaria.
Area of Science:
- Tropical Medicine
- Infectious Diseases
- Public Health
Background:
- Malaria affects 300-500 million people annually, causing significant mortality from severe falciparum malaria.
- Uncomplicated malaria can escalate to severe disease, become chronic, or resolve based on host immunity and treatment access.
Purpose of the Study:
- To compare the effectiveness of artemisinin combination treatments (ACTs) versus non-ACTs for malaria in endemic regions (excluding Southeast Asia).
- To identify the most effective ACT for malaria treatment in endemic areas.
Main Methods:
- Systematic review of 18 studies including systematic reviews, RCTs, and observational studies.
- Searched major databases (Medline, Embase, Cochrane Library) up to November 2006.
- Included safety alerts from regulatory agencies (FDA, MHRA).
Main Results:
- The review synthesized evidence on the effectiveness and safety of various ACTs.
- GRADE evaluation was used to assess the quality of evidence for interventions.
Conclusions:
- Information on the effectiveness and safety of amodiaquine plus sulfadoxine-pyrimethamine, artemether-lumefantrine, artesunate plus mefloquine, artesunate plus amodiaquine, and artesunate plus sulfadoxine is presented.
- This systematic review provides evidence to inform the selection of optimal ACTs for malaria treatment.
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