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Related Experiment Video

Updated: Jun 23, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Systemic lupus erythematosus.

Rajan Madhok1, Olivia Wu

  • 1Glasgow Royal Infirmary, Glasgow, UK.

BMJ Clinical Evidence
|May 21, 2009
PubMed
Summary
This summary is machine-generated.

This systematic review evaluates treatments for systemic lupus erythematosus (SLE), focusing on joint, skin, kidney, and neuropsychiatric symptoms. It summarizes evidence on various interventions for SLE management.

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Last Updated: Jun 23, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Area of Science:

  • Rheumatology
  • Systemic Autoimmune Diseases
  • Evidence-Based Medicine

Background:

  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with variable global prevalence.
  • SLE predominantly affects young women but also occurs in children, with differing rates across demographics.

Purpose of the Study:

  • To systematically review the effectiveness of treatments for joint and non-organ-threatening symptoms in SLE.
  • To assess interventions for cutaneous, lupus nephritis (proliferative), and neuropsychiatric manifestations of SLE.

Main Methods:

  • Conducted a systematic literature review up to April 2006, searching major databases.
  • Included randomized controlled trials (RCTs), observational studies, and harms alerts from regulatory agencies.
  • Utilized GRADE methodology to evaluate the quality of evidence for interventions.

Main Results:

  • Identified eight systematic reviews, RCTs, or observational studies meeting inclusion criteria.
  • Evaluated the effectiveness and safety of numerous interventions for SLE symptoms.
  • Evidence quality was assessed using the GRADE framework.

Conclusions:

  • Presents findings on the effectiveness and safety of interventions including corticosteroids, hydroxychloroquine, methotrexate, and others.
  • Provides a summary of evidence for managing diverse SLE manifestations.
  • Highlights key treatments for SLE, informing clinical practice.