Polymeric micelles of ammonium palmitoyl glycol chitosan and solubilization of camptothecin
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Updated: Jun 23, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
1Department of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan. drnazarmranjha@yahoo.com
Abstract:
Chitosan is a polysaccharide possessing biodegradable and biocompatible properties. Chitosan and its derivatives are used as excipients in drug delivery, as mucoadhesive polymers, and as a permeation enhancer for drug delivery in vitro at mucosal epithelia; and micelles of chitosan derivatives are used for solubilization of hydrophobic drug. Twenty-five samples of ammonium palmitoyl glycol chitosan were synthesized after reacting glycol chitosan with palmitic acid N-hydroxysuccinimide and methyl iodide with different concentration of hydrophobic and hydrophilic component. The objective was to identify suitable combinations of hydrophilicity and hydrophobicity which dissolve maximum water-insoluble camptothecin drug. In conclusion, the more hydrophilic and hydrophobic polymers are not suitable for solubilization of camptothecin.
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