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Aripiprazole in treatment-refractory schizophrenia
Wen-Yu Hsu1, Chien-I Lee, Nan-Ying Chiu
1Changhua Christian Hospital, Changhua, Taiwan.
Journal of Psychiatric Practice
|May 23, 2009
Summary
Switching from clozapine to aripiprazole can be a viable option for patients with treatment-refractory schizophrenia experiencing adverse effects. This case study highlights successful management of psychotic symptoms after the medication switch.
Area of Science:
- Psychiatry
- Pharmacology
Background:
- Clozapine is a primary treatment for treatment-refractory schizophrenia.
- However, clozapine use is associated with potential adverse effects and tolerability issues.
Observation:
- A 58-year-old female patient with treatment-refractory schizophrenia experienced consciousness changes while on clozapine 300 mg/day.
- The patient was successfully switched to aripiprazole 20 mg/day.
Findings:
- Following the switch to aripiprazole, the patient's psychotic condition showed improvement.
- Literature search revealed limited successful cases of switching from clozapine to other antipsychotics.
Implications:
- For patients intolerant to clozapine or at risk of physical complications, alternative antipsychotic strategies are necessary.
- Clinicians may consider switching to a different antipsychotic or using combination therapy with a reduced clozapine dosage.
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