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Related Experiment Video

Updated: Jun 23, 2026

Tissue Engineering of the Intestine in a Murine Model
08:45

Tissue Engineering of the Intestine in a Murine Model

Published on: December 1, 2012

Current perspectives on pediatric intestinal transplantation.

George V Mazariegos1, Robert H Squires, Rakesh K Sindhi

  • 1Children's Hospital of Pittsburgh, Pittsburgh, PA 15213, USA. george.mazariegos@chp.edu

Current Gastroenterology Reports
|May 26, 2009
PubMed
Summary

Pediatric intestinal failure, often from surgical issues or motility disorders, may necessitate intestine transplantation. Centers of excellence report high survival rates, with research focused on reducing chronic rejection.

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Area of Science:

  • Pediatric surgery
  • Gastroenterology
  • Transplantation immunology

Background:

  • Pediatric intestinal failure stems from surgical conditions (e.g., necrotizing enterocolitis, gastroschisis) or functional disorders (e.g., intestinal pseudo-obstruction, microvillus inclusion disease).
  • Intestine replacement becomes necessary for severe cases impacting growth and quality of life.

Purpose of the Study:

  • To outline the indications, surgical approaches, immunosuppression protocols, and outcomes of intestinal transplantation in children.
  • To highlight the current survival rates and future research directions in pediatric intestinal transplantation.

Main Methods:

  • Review of indications for intestinal transplantation, including liver dysfunction, central line complications, and severe dehydration.
  • Description of surgical techniques: isolated intestine, combined liver-intestine, and multivisceral transplantation.
  • Summary of immunosuppression regimens, primarily tacrolimus-based with induction therapy.

Main Results:

  • Centers of excellence report 1-year patient survival rates of 95% and 5-year survival rates of 77%.
  • Key indications include liver dysfunction, loss of venous access, and recurrent sepsis or dehydration.

Conclusions:

  • Intestinal transplantation is a viable option for children with irreversible intestinal failure, offering significant survival benefits.
  • Ongoing research aims to mitigate long-term graft loss, particularly from chronic rejection, to further improve patient outcomes.