[Level and clinical significance of soluble CD40 in patients with chronic hepatitis B]

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Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
04:11

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA

Published on: December 15, 2023

Hong-hui Shen1, Hong-yan Sun, Jing-min Zhao

  • 1Laboratory of Virology, Institute of Infectious Diseases, Beijing 302 Hospital, Beijing 100039, China.

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi = Zhonghua Shiyan He Linchuang Bingduxue Zazhi = Chinese Journal of Experimental and Clinical Virology
|May 28, 2009
PubMed

Insights

Soluble CD40 (sCD40) levels are elevated in chronic hepatitis B patients and correlate with severe liver inflammation and necrosis. This immunological marker aids in assessing disease status.

Area of Science:

  • Immunology
  • Hepatology
  • Biomarker Discovery

Background:

  • Chronic hepatitis B (CHB) is a significant global health concern.
  • Understanding immunological markers in CHB is crucial for disease management.

Purpose of the Study:

  • To investigate the levels of soluble CD40 (sCD40) in CHB patients.
  • To determine the clinical significance and correlation of sCD40 with liver inflammation and necrosis.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to measure sCD40 concentrations.
  • 176 CHB patients and healthy controls were included.
  • Correlation analysis was performed between sCD40 levels and liver histopathology.

Main Results:

  • sCD40 levels were significantly higher in CHB patients compared to healthy individuals.
  • sCD40 concentration showed a positive correlation with the severity of liver inflammation and necrosis.
  • In patients with ALT < 80 IU/L and sCD40 > 80 pg/ml, 65.85% exhibited high-grade liver inflammation and necrosis.

Conclusions:

  • sCD40 concentration is a valuable immunological index for evaluating the grade of liver inflammation and necrosis in CHB.
  • Elevated sCD40 levels indicate a more severe disease state in CHB patients.
Abstract

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