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Related Concept Videos

Micelles01:30

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
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Solution, Solubility, and Solubility Equilibrium
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
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Surface Active Agents01:27

Surface Active Agents

Surfactants, named for their behavior at interfaces, positively adsorb at the interfaces of two phases, reducing interfacial tension. Their versatility as emulsifiers, detergents, and foaming agents stems from this ability. Surfactants, often termed amphiphiles, share the property of amphipathy, with molecules having both hydrophilic and hydrophobic portions. The hydrophilic part is called the head, and the hydrophobic part, including an elongated alkyl substituent, forms the tail.Surfactants...
The Colloidal State01:29

The Colloidal State

The formation of a colloidal system is exemplified by an aqueous solution containing Cl− ions is introduced to another containing Ag+ ions, resulting in the precipitation of solid AgCl as extremely tiny crystals. Instead of settling out as a filterable precipitate, these crystals remain suspended in the liquid, showcasing a colloidal system.A colloidal system involves colloidal particles within the approximate range of 1 to 1000 nm in at least one dimension, dispersed in a medium called the...

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Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
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Phospholipids embedded fully dilutable liquid nanostructures. Part 1: compositions and solubilization capacity.

Orit Amsalem1, Idit Yuli-Amar, Abraham Aserin

  • 1Casali Institute of Applied Chemistry, The Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. orit.amsallem@mail.huji.ac.il

Colloids and Surfaces. B, Biointerfaces
|May 29, 2009
PubMed
Summary

Phospholipids (PL) form unique, water-dilutable nanostructures for drug delivery. These phosphatidylcholine (PC)-based systems self-assemble into direct micelles and O/W microemulsions, even with minimal water content.

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Area of Science:

  • Colloid and Surface Chemistry
  • Materials Science
  • Pharmaceutical Sciences

Background:

  • Phospholipids (PL) are versatile surfactants for creating micellar systems and microemulsions, crucial for drug delivery applications.
  • Conventional systems often require combinations of surfactants, cosolvents, and cosurfactants to achieve desired nanostructures.
  • Understanding self-assembly behavior is key to designing effective delivery vehicles.

Purpose of the Study:

  • To incorporate phosphatidylcholine (PC) into novel U-type, water-dilutable phase diagrams.
  • To investigate the formation and characteristics of nanostructures derived from food-grade emulsifiers.
  • To explore the self-assembly of water-free concentrates into various nanodroplets and microemulsions upon water dilution.

Main Methods:

  • Preparation of water-free concentrates using phosphatidylcholine (PC) and other food-grade emulsifiers.
  • Characterization of nanostructures formed upon dilution with water, focusing on micelle type and composition.
  • Systematic variation of oil phase, surfactant types, cosurfactants, and PL properties (headgroups, tail length).

Main Results:

  • Unique U-type phase diagrams with extensive isotropic regions of nanostructures were achieved.
  • Water-free concentrates self-assembled into direct micelles (hydrophilic headgroups outward) even without water.
  • Upon water addition, systems formed oil-in-water (O/W) microemulsions, stable even at low water concentrations (0-20 wt%).
  • Decreasing triacetin and PC content significantly enhanced the isotropic region.

Conclusions:

  • Phosphatidylcholine (PC) enables the creation of novel, water-dilutable nanostructured systems for potential drug delivery.
  • The designed systems exhibit unique self-assembly into direct micelles and stable O/W microemulsions.
  • Tailoring PL composition and system components offers control over dilution capabilities and nanostructure formation.