Development of polymeric films embedded with liquid nanodomains

Area of Science:

• Materials Science
• Pharmaceutical Sciences
• Nanotechnology

Background:

• Modified microemulsions (MEs), termed nanodomains (NDs), are promising for dermal drug delivery due to their composition.
• Liquid NDs lack controlled release capabilities for transdermal drug delivery.
• Polymeric films are explored as a platform to overcome limitations of liquid NDs for controlled release.

Purpose of the Study:

• To develop a polymeric film platform capable of embedding liquid nanodomains (NDs) for controlled drug release.
• To understand the challenges in preparing films that preserve ND integrity.
• To achieve homogeneous, transparent films with high ND loading capacity.

Main Methods:

• Investigated film formation using 'nanodomains destructive polymers' versus 'constructive polymers'.
• Utilized fundamental structural techniques to analyze film properties and ND reconstitution.
• Performed thermal behavior studies to assess water states within the film and NDs.

Main Results:

• Identified 'constructive polymers' that form homogeneous, transparent films with up to 90 wt% ND loading, unlike 'destructive polymers'.
• Demonstrated reconstitution of NDs with original structure and ~12 nm droplet size upon film redissolution.
• Observed absence of 'free' or 'bulk' water in the film, contrasting with liquid NDs.

Conclusions:

• Developed a stable polymeric film platform for embedding liquid nanodomains.
• The film platform facilitates controlled, long-term drug release for dermal applications.
• This approach enhances the therapeutic potential of nanodomain-based drug delivery systems.