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Updated: Jun 22, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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miRNA Expression Analyses in Prostate Cancer Clinical Tissues

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Predictive value of prostate-specific antigen expression in prostate cancer: a tissue microarray study.

Andreas Erbersdobler1, Hendrik Isbarn, Isabel Steiner

  • 1Institute of Pathology, Charité University Medical Center, Berlin, Germany. andreas.erbersdobler@charite.de

Urology
|May 30, 2009
PubMed
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Loss of prostate-specific antigen (PSA) expression in prostate cancer tissue correlates with adverse features but doesn't independently predict recurrence. It may help predict extraprostatic extension in specific patient groups.

Area of Science:

  • Urologic Oncology
  • Cancer Biomarkers
  • Prognostic Factors

Background:

  • Serum prostate-specific antigen (PSA) is a key tool for prostate cancer diagnosis and prognosis.
  • The prognostic value of PSA expression within tumor tissue remains less understood in large cohorts.
  • Evaluating tumor markers alongside clinical data is crucial for refining prostate cancer management.

Purpose of the Study:

  • To assess the prognostic significance of prostate-specific antigen (PSA) expression in prostatectomy tumor specimens.
  • To investigate the association between PSA expression levels and clinical outcomes in a large prostate cancer cohort.
  • To determine if intratumoral PSA expression is an independent predictor of PSA recurrence post-prostatectomy.

Main Methods:

  • Utilized a tissue microarray with 3261 prostatectomy specimens.

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  • Quantified PSA expression via immunohistochemical staining (scale 0-3).
  • Correlated PSA expression with clinical, pathological parameters, and follow-up data in 2556 eligible tumors.

    • Main Results:

    • 48.0% of tumors showed strong PSA expression, 36.7% moderate, 12.2% weak, and 3.1% absent.
    • Loss of PSA expression significantly correlated with higher Gleason scores and extraprostatic extension.
    • PSA expression loss was linked to PSA recurrence on univariate but not multivariate analysis.

    Conclusions:

    • Loss of intratumoral PSA expression is associated with adverse pathological features and clinical outcomes.
    • Intratumoral PSA expression is not an independent prognostic factor for PSA recurrence after prostatectomy.
    • Reduced PSA expression may aid in predicting extraprostatic tumor extension in specific biopsy scenarios and patient subgroups.